Μechanism for the aerobic exercise-induced decrease in triacylglycerol concentration in young healthy women

Aim: To investigate the mechanism for the hypotriacylglycerolemic effect of one bout of aerobic exercise in women.

Material-Methods: Eight healthy sedentary women (age: 23.5±2.7 years, BMI: 22.1±1.2 kg/m2, VO2peak: 1.6±0.4L/min) participated in two stable isotope-labeled tracer infusion studies the day after (a) exercise: brisk walking at 60% of peak oxygen consumption (energy deficit of ~500 kcal) and (b) control (rest, zero energy balance) in a random order.
Results: Mean exercise duration was 125±19 min. Fasting plasma TAG levels were 11% lower the day after exercise compared to control (43.1±5.0 and 49.7±9.3 mg/dL respectively, P<0.05) whereas VLDL-TAG levels were 29% lower (12.7±4.1 and 18.2±5.3 mg/dl respectively, P<0.01). Hepatic VLDL-TAG secretion rate (3.62±0.98 and 4.52±1.56 μmol/min, exercise vs control respectively, P>0.05) did not change significantly. Exercise increased VLDL-TAG clearance rate by 21% (26.81±7.27 and 22.31±4.98 mL/min, exercise vs control respectively; P<0.05). Mean residence time of VLDL-TAG did not change significantly after exercise compared to control (87±22 and 102±19 min, P>0.05).

Conclusion: The hypotriacylglycerolemic effect of one bout of aerobic exercise in women is manifested via an increase in VLDL-TAG clearance rate